HDL cholesterol efflux capacity and lipid profile in patients with systemic sclerosis

Abstract Objective It is well established that patients with systemic sclerosis (SSc) have a disrupted lipid profile and an increased cardiovascular risk. Cholesterol efflux capacity (CEC), the ability of high-density lipoprotein (HDL)-cholesterol to accept cholesterol from macrophages, has been linked events. The aim this study was establish whether CEC were impaired in SSc respect controls these changes associated disease-related data. Methods Cross-sectional encompassed 188 individuals: 73 115 controls. CEC, using vitro assay, serum concentrations assessed A multivariable analysis performed differences between controls, if SSc-related data could explain such differences. Results adjusted for demographic characteristics, risk factors, lipid-related molecules showed total (beta coefficient: − 22 [95%CI – 37 7], p = 0.004), triglycerides 24 2–47], 0.033), 2–43], 6 10 2]%, 0.002) significantly different Skin thickness, as by modified Rodnan skin score, independently lower 0.21 0.37 0.05]%, 0.011) after adjustment. Conclusion show abnormal including CEC. thickness independent inversely patients.